Double-Strength SAMe 400 mg

SAM-e (S-Adenosyl Methionine) is derived from the amino acid methionine and ATP (Adenosine Triphosphate). ATP is normally synthesized in the body but may become depleted from sickness and aging. SAM-e is concentrated in the liver and brain and has multiple mechanisms of action in the body. As a major methyl donor, it synthesizes hormones, nucleic acids, proteins, phospholipids, catecholamines, and other neurotransmitters. SAM-e and Mood and Cognitive Function SAM-e?s ability to boost brain cell methylation facilitates youthful DNA enzymatic actions which may help account for its mood-elevating properties. These enzymatic actions are required for the healthy conversion of neurotransmitters, such as serotonin and dopamine. SAM-e also facilitates glutathione usage which improves the body?s antioxidant defense and it helps maintain acetylcholine levels necessary for cognitive function.* YDRB151-1 Supplementing with SAMe The manufacturing process of SAMe yields two forms, the S,S and R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in our SAMe 400 is processed to yield the highest available percentage of the active pure S,S form on the market. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving. SAM-e and Liver Function In order to perform its detoxification role, SAM-e facilitates healthy methylation enzymatic processes and boosts hepatic levels of glutathione, a critical antioxidant which helps protect against free radicals. SAM-e acts as a methyl donor in the synthesis and formation of phosphatidylcholine and L-cysteine, both necessary for maintaining liver health.* Enhances Mood & Neural Function Promotes Joint Comfort & Mobility Supports Liver Health & Detoxification SAM-e and Joint Function In clinical trials, SAM-e has been shown to help reduce pain in joints and increase joint comfort and mobility by promoting the synthesis of proteoglycans, essential components of connective tissue.*

Gluten Free / Soy Free Vegan Our Double-Strength SAMe 400 contains 400mg of active SAMe in each tablet.

Individuals diagnosed wit bipolar disease or manic depression should avoid supplementing with SAMe. Warning: Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Do not use if pregnant or nursing. May cause gastrointestinal discomfort is a small percentage of people.